Tag Archives: health-sciences

Best And Worst Q2’16: Healthcare ETFs, Mutual Funds And Key Holdings

The Health Care sector ranks seventh out of the ten sectors as detailed in our Q2’16 Sector Ratings for ETFs and Mutual Funds report. Last quarter , the Health Care sector ranked sixth. It gets our Dangerous rating, which is based on aggregation of ratings of 22 ETFs and 80 mutual funds in the Health Care sector. See a recap of our Q1’16 Sector Ratings here . Figures 1 and 2 show the five best and worst rated ETFs and mutual funds in the sector. Not all Health Care sector ETFs and mutual funds are created the same. The number of holdings varies widely (from 23 to 351). This variation creates drastically different investment implications and, therefore, ratings. Investors seeking exposure to the Health Care sector should buy one of the Attractive-or-better rated ETFs or mutual funds from Figures 1 and 2. Figure 1: ETFs with the Best & Worst Ratings – Top 5 Click to enlarge * Best ETFs exclude ETFs with TNAs less than $100 million for inadequate liquidity. Sources: New Constructs, LLC and company filings Figure 2: Mutual Funds with the Best & Worst Ratings – Top 5 Click to enlarge * Best mutual funds exclude funds with TNAs less than $100 million for inadequate liquidity. Sources: New Constructs, LLC and company filings Saratoga Advantage Health & Biotechnology Portfolio (SBHIX, SHPCX) and Live Oak Health Sciences Fund (MUTF: LOGSX ) are excluded from Figure 2 because their total net assets are below $100 million and do not meet our liquidity minimums. iShares Global Healthcare ETF (NYSEARCA: IXJ ) is the top-rated Health Care ETF and Schwab Health Care Fund (MUTF: SWHFX ) is the top-rated Health Care mutual fund. IXJ earns an Attractive rating and SWHFX earns a Neutral rating. BioShares Biotechnology Products Fund (NASDAQ: BBP ) is the worst rated Health Care ETF and Alger Health Sciences Fund (MUTF: AHSAX ) is the worst rated Health Care mutual fund. Both earn a Very Dangerous rating. 354 stocks of the 3000+ we cover are classified as Health Care stocks. Gilead Sciences (NASDAQ: GILD ) is one of our favorite stocks held by IXJ and earns a Very Attractive rating. Gilead has built a highly profitable business in the biotech industry and has grown after-tax profit ( NOPAT ) by an impressive 39% compounded annually since 2005. Over the same time frame, Gilead has increased its return on invested capital ( ROIC ) from an already high 37% in 2005 to a top-quintile 88% in 2015. Over the past five years, Gilead has generated a cumulative $26 billion in free cash flow. Despite the operational successes, GILD remains undervalued. At its current price of $98/share, GILD has a price-to-economic book value ( PEBV ) ratio of 0.6. This ratio means that the market expects Gilead’s NOPAT to permanently decline by 40%. However, if Gilead can grow NOPAT by just 4% compounded annually for the next five years , the stock is worth $181/share today – an 85% upside. Eli Lilly (NYSE: LLY ) is one of our least favorite stocks held by AHSAX and earns a Dangerous rating. Over the past five years, Eli Lilly’s NOPAT has declined by 12% compounded annually. The company’s ROIC has fallen from 21% in 2010 to only 8% in 2015. NOPAT margins have followed a similar path and fallen from 24% in 2010 to 14% in 2015. In the meantime, LLY has increased 25% over the past two years, which has left shares overvalued. To justify its current price of $75/share, Eli Lilly must grow NOPAT by 8% compounded annually for the next 14 years . This expectation seems awfully optimistic given the deterioration of LLY’s business operations. Figures 3 and 4 show the rating landscape of all Health Care ETFs and mutual funds. Figure 3: Separating the Best ETFs From the Worst ETFs Click to enlarge Sources: New Constructs, LLC and company filings Figure 4: Separating the Best Mutual Funds From the Worst Mutual Funds Click to enlarge Sources: New Constructs, LLC and company filings D isclosure: David Trainer and Kyle Guske II receive no compensation to write about any specific stock, sector or theme. Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it. I have no business relationship with any company whose stock is mentioned in this article.

Healthcare Mutual Funds To Bounce Back After Q1 Debacle: 5 Picks

The healthcare space was mostly out of favor in the first quarter following Democratic Presidential Candidate, Hillary Clinton’s allegation on “price gouging.” The massive decline in Valeant Pharmaceuticals International, Inc.’s (NYSE: VRX ) shares also had an adverse impact on biotech stocks, eventually dragging the healthcare sector down. Healthcare mutual funds weren’t spared as the category turned out to be the worst performer in the first quarter. Foremost funds from the healthcare space failed to end in positive territory during the period. Despite this hiccup, investors shouldn’t be demoralized as the long term bodes well for such funds. The healthcare sector is poised to gain from an ageing population both at home and abroad. And with an increase in mergers, and innovative product pipelines and approvals, it’s just a matter of time before the sector bounces back. Not to forget that biotech stocks have already rebounded in the past few days after being torn apart in the first three months of the year. Banking on this optimism, it will be prudent to invest in healthcare funds that have given solid returns over a long period of time and also boast strong fundamentals. (Read: 3 Healthcare Funds to Buy on Biotech Rebound ) Healthcare Losing Ground in Q1 It’s been an awful first quarter for the healthcare sector. Political scrutiny about drug prices took a toll on healthcare stocks. Healthcare Equity Funds nosedived 13.28% during the first quarter, according to Morningstar. Among the worst performing drug makers were Mallinckrodt Public Limited Company (NYSE: MNK ), Horizon Pharma plc (NASDAQ: HZNP ) and Endo International plc (NASDAQ: ENDP ), whose shares plunged 17.9%, 21.4% and 54%, respectively, in the first quarter. If you think that was bad, then biotechs had it even worse. The iShares NASDAQ Biotechnology Index plummeted almost 23% in the first quarter. The Valeant Pharmaceuticals disaster was also responsible for the significant underperformance. U.S. lawmakers investigating Valeant’s pricing practices, accusations about accounting irregularities and delay in filing annual reports practically ruined the company. In the first quarter alone, Valeant’s shares plummeted 36.8%. With the new tax inversion rules the pain seems to have intensified. According to the U.S. Treasury Department and Internal Revenue Service, the rule bars U.S. companies from undertaking inversion transactions if they have done so in the past three years. These inversion deals were a ploy for U.S. drug companies to dodge tax bills by relocating their headquarters abroad. On the earnings front, things are also looking gloomy. First-quarter earnings from the healthcare sector are anticipated to grow a meager 0.6% from the year-ago level compared with 9.3% growth witnessed in the previous quarter. (Read: Previewing the Q1 Earnings Season ) Tailwinds are Strong Even though healthcare witnessed a dismal first quarter, the sector is positioned to grow in the future thanks to an ageing American population. There are about 77 million U.S. baby boomers, which is quite a significant number. An ageing population bodes well for the healthcare sector as they require more medical attention. Along with it, an ageing China also provides long-term opportunities for both U.S. pharmaceutical and medical technology companies. The need to trim costs and tap growth opportunities are driving healthcare firms into mergers and acquisitions (M&A). Additionally, the Fed’s dovish outlook to proceed cautiously on hiking rates is also expected to boost M&A deals. Also, the first FDA-approved biosimilar, Zarxio, hit the market last year. Biotech companies are now vying to enter this high revenue generating space. Several other products such as Imlygic, Ibrance, Strensiq, Genvoya and, PCSK9 inhibitors, Praluent and Repatha also got approved. This in turn is expected to help companies from the healthcare space to generate steady revenues. Thanks to the mandated healthcare coverage in the U.S., more Americans are seeking treatment, which is also a net positive for healthcare firms. 5 Healthcare Mutual Funds to Invest In As discussed above, these tailwinds may collectively act as growth facilitators and help the healthcare sector overcome the drubbing it took in the first quarter. In case of inversion rules, healthcare companies will continue to seek creative ways to relocate their tax residence to avoid paying the lofty taxes at home, as per the Treasury Secretary Jacob J. Lew. Since the long run holds good for the healthcare sector, it will be wise to buy mutual funds associated with the sector. These funds have yielded positive returns for a long time despite being in the red in the first quarter. Moreover, these funds are fundamentally solid, which will eventually help them gain in the future as well. We have selected five healthcare mutual funds that have impressive 3-year and 5-year annualized returns and carry a Zacks Mutual Fund Rank #1 (Strong Buy) or #2 (Buy). These funds also possess a relatively low expense ratio and have minimum initial investment within $5000. T. Rowe Price Health Sciences Fund (MUTF: PRHSX ) invests a large portion of its assets in companies engaged in the development and distribution of health care products. PRHSX’s 3-year and 5-year annualized returns are 19.7% and 21.1%, respectively. Annual expense ratio of 0.76% is lower than the category average of 1.35%. PRHSX has a Zacks Mutual Fund Rank #1. Fidelity Select Health Care Portfolio (MUTF: FSPHX ) invests a major portion of its assets in companies involved in the manufacture and sale of products used in connection with health care. FSPHX’s 3-year and 5-year annualized returns are 19.2% and 18.8%, respectively. Annual expense ratio of 0.74% is lower than the category average of 1.35%. FSPHX has a Zacks Mutual Fund Rank #2. Hartford Healthcare Fund A (MUTF: HGHAX ) invests the majority of its assets in the equity securities of health care-related companies worldwide. HGHAX’s 3-year and 5-year annualized returns are 17.3% and 17.7%, respectively. Annual expense ratio of 1.28% is lower than the category average of 1.35%. HGHAX has a Zacks Mutual Fund Rank #2. Live Oak Health Sciences Fund (MUTF: LOGSX ) invests a large portion of its assets in equity securities of health sciences companies. LOGSX’s 3-year and 5-year annualized returns are 16.1% and 15.7%, respectively. Annual expense ratio of 1.08% is lower than the category average of 1.35%. LOGSX has a Zacks Mutual Fund Rank #2. Fidelity Select Biotechnology Portfolio (MUTF: FBIOX ) invests the majority of its assets in companies engaged in the manufacture and distribution of various biotechnological products. FBIOX’s 3-year and 5-year annualized returns are 16.1% and 23.7%, respectively. Annual expense ratio of 0.74% is lower than the category average of 1.35%. FBIOX has a Zacks Mutual Fund Rank #2. Link to the original post on Zacks.com

Healthcare And Biotechnology Closed-End Funds

Summary Tekla offers four closed end funds in the biotechnology/healthcare sector. Two long-established funds are focused on capital growth. Two newer funds add current income to their investment objectives. Healthcare and Biotechnology seem to have caught their stride after a rough third quarter. There are a lot of ways to invest in these sectors. One of the least appreciated is closed-end funds, and the best of these, in my opinion, come from Tekla. Tekla sponsors four funds. Two are well established funds that are regularly found at or near the top of the pack for equity CEFs. Two are new, one a little more than a year old and the other a little more than a quarter. The stalwarts are Tekla Healthcare Investors (NYSE: HQH ) and Tekla Lifesciences Investors (NYSE: HQL ). The new-comers are Tekla Healthcare Opportunities (NYSE: THQ ) and Tekla World Healthcare (NYSE: THW ). Some descriptive details for these funds are in the table. The two older funds operate much the same. They are unleveraged and have managed distribution policies for their quarterly distributions. The younger funds are structured differently from the older funds, but are similar to each other. For one thing, they use leverage to achieve their investment goals. Precisely what the extent of that leverage may eventually be is unclear. THQ is reporting 9.6% leverage at present, and THW is too new to have reported. THQ and THW also have managed distribution policies, but theirs are structured differently from HQH and HQL. They pay distributions monthly. Investment Goals HQH invests in the healthcare industry (including biotechnology, medical devices, and pharmaceuticals). The fund’s objective is to provide long-term capital appreciation through investments in companies in the healthcare industry believed to have significant potential for above-average long-term growth. Selection emphasizes the smaller, emerging companies with a maximum of 40% of the Fund’s assets in restricted securities of both public and private companies. HQL primarily invests in the life sciences (including biotechnology, pharmaceutical, diagnostics, managed healthcare, medical equipment, hospitals, healthcare information technology and services, devices and supplies), agriculture and environmental management industries. The Fund’s objectives and selection criteria are the same as HQH except for a change in wording from healthcare to the life sciences industry. Note that biotechnology heads the lists for each. To a large extent these are primarily biotech funds. One particularly interesting point is that the funds can and do invest in private companies. This can open opportunities not generally available to most investors, and certainly not readily accessible by investing in open-end mutual funds or ETFs. The difference between HQH and HQL is that HQL’s mandate is expanded to include agricultural and environmental biotechnologies. THQ and THW invest primarily in the healthcare industry. The funds’ objectives are to seek current income and long-term capital appreciation through investment companies engaged in the healthcare industry, including equity securities, debt securities and pooled investment vehicles. Notice that HQH and HQL make no mention of current income in their goal statements and THQ and THW do. Notice also, that THQ and THW include debt securities in their investment strategies. THW differs from THQ in being targeted more as an international fund. It expects to invest at least 40% in companies organized or located outside the United States. Both expect to invest in debt securities and pooled investment vehicles in addition to equity. So there are marked differences between HQH and HQL on one hand, and THQ and THW on the other. HQH/HQL are more closely focused on biotech; THQ/THW invest more broadly in the healthcare sector. The first set does provide excellent income, but that is not its purpose, which affects how the fund is managed. Finally the new funds expand their investment programs to include debt securities such as convertible and non-convertible bonds and preferred shares. Distribution Policies All four have managed distribution policies, but the terms of the policies are different. HQH and HQL have as their distribution policy the intention to make quarterly distributions at a rate of 2% of the fund’s net assets. To the extent possible, they will to do so using net realized capital gains. If those gains fall short of the target this could result in return of capital to shareholders. Capital gains in excess of distributions will be returned to shareholders as a special distribution with the December distribution. The default for HQH’s and HQL’s distributions is that they are taken in stock. Investors do have the option to request cash distributions. This policy reflects the funds’ emphases on capital appreciation rather than current income, and is unusual for CEFs. Both HQH and HQL began making quarterly distributions in 2000 (previous to that they were made annually). Both suspended distributions for three quarters in 2009-10 making no payment between June 2009 and June 2010. Otherwise, the funds have met their 2% of NAV payout objective without return of capital for all but two of the 60 quarterly payments they have made. Distributions for Q1 and Q2 of 2009, the quarters prior to the suspension of distributions did include return of capital. THQ and THW have current income as an investment objective. Their managed distribution policies are more similar to that of other managed-distribution CEFs. Although I have not seen it explicitly stated in the materials I’ve viewed, I assume that it means the funds expect to maintain consistent monthly payments independent of fluctuations in NAV and income, which is the most typical pattern of managed distributions. This can mean distributions that include return of capital and periodic occurrences of negative undistributed net investment income. THQ has paid $0.1125/share monthly since inception. THW has paid $0.1167/share for its three distributions. Current Status The two older funds are currently priced at premiums near 5%. The new funds have double-digit discounts as seen in this table. The distribution percentages shown in the table are based on recent payouts. According the funds’ policies the next distribution for HQH and HQL will be 2% of NAV on the record date. Z-Scores give us an indication of where the discount/premium stands in relation to the past. Positive Z-Scores mean the discount has shrunk or the premium has grown over the period. The absolute value represents the number of standard deviations the current value is relative to the average for the period. Large Z-scores (say, over 2 or under -2) can often suggest mean reversion is imminent. These values tell us that for HQH and HQL the premiums stand well above their means for 3, 6 and 12 months. As recently as the end of September, HQH had a -8.85% discount and HQL’s was -6.2%. Both funds have seen volatile pricing relative to NAV recently and have seen their discount/premium fluctuate widely. This is seen in HQH’s chart (from cefconnect.com ). (click to enlarge) During the third quarter meltdown for healthcare and biotechnology there was near-panic selling of the fund causing the discount to fall below -8%. With signs of recovery in October, the premium has been restored. These are the sorts of movements that some CEF investors look for and hope to take advantage of when they do occur. Portfolios HQH and HQL have very similar portfolios. HQL nominally adds exposure to agricultural and environmental biotechnology to HQH’s pure play in healthcare but this not obvious without getting deep into the fund’s holdings. At the top it looks very much like HQH. HQH holds 96% in equity; for HQL it’s 92%. The remainder is primarily in debt instruments. THQ holds 18.5% of its portfolio in debt instruments. THW’s portfolio remains a black box at this time, as there have been no reports as yet by the fund. Top holdings are available for HQH, HQL and THL but not for THW. (click to enlarge) Note how similar HQH and HQL’s lists are. The clear emphasis here is on biotechnology. THQ has positions extending beyond biotechnology to include more traditional healthcare companies such as Johnson & Johnson and Pfizer which is consistent with its more explicit emphasis on income. Other Healthcare CEFs My focus here has been on the Tekla offerings with the intention of clarifying how the new funds differ from the established funds. Before closing, I would be remiss to not mention two other healthcare CEFs; BlackRock Health Sciences (NYSE: BME ) and Gabelli Health & Wellness (NYSE: GRX ). BRE is more similar to HQH and HQL in that it is unleveraged and entirely domestic, but its focus is less on biotechnology than those funds. GRX carries 20.5% effective leverage and has a more diverse portfolio that includes food companies such as Kraft Foods and Kikkomann Corp as well as heathcare holdings. It is 84% domestic and 15% Developed Europe and Japan. BME, like the older Tekla funds shows extensive movement in its premium/discount. It now stands at a 7% premium, up from its 52 week average but well below its 52 week high of 16.2%. GRX, by contrast, tends toward a persistent discount which is now -13.2%, near its 52 week low of -14.8%. BME recently has tended to perform comparably to the Tekla funds; GRX has consistently lagged. Over a longer time frame the Tekla funds have turned in much stronger performances than either BRE or GRX, likely a reflection of their emphasis on biotechnology over traditional healthcare companies. This is illustrated by this chart tracking total return for the past two and five years. (click to enlarge) Summary The two sets of Tekla funds, HQH and HQL on one hand, and THQ and THW on the other, have different objectives and approaches to healthcare and biotechnology investing strategies. HQH and HQL are primarily focused on generating capital appreciation. The younger funds are more in the traditional CEF mold of emphasizing current income as well as capital appreciation. Despite the lack of formal emphasis on income, the distribution policies of HQH and HQL are, in my view, primarily attractive to an investor interested in current income. Their distribution yields are attractive and growing with NAV growth. For a shareholder invested for capital appreciation, the distributions can raise tax issues, so the funds are probably best held in a tax-advantaged account in such cases. In a taxable account, it would seem to make more sense to use ETFs to provide exposure to biotechnology to satisfy a capital growth objective. ETFs can effectively provide that capital appreciation with much lower taxable distributions. The premiums for HQH and HQL argue against entry into these funds at this time. A patient investor would probably choose to wait for some reduction in the premiums, if not outright reversion to discount status. Those premiums are now approaching all-time highs for HQL and are at rarely seen levels for HQH. An income investor seeking exposure to healthcare with a biotech focus may find THQ more appealing than either HQH or HQL at this time. There is, of course, only a scant record for the fund. Tekla has shown itself to be a strong manager of biotech equity portfolios but has little record in expanding that to include debt and credit. The discount of -11.6%, about as deeply discounted as the fund has been in its short life, looks to provide an attractive entry. As for THW, the fund is too young and information too scanty to appeal to me at this time. I suspect it will evolve to be as similar to THQ as HQL is to HQH.