Tag Archives: amgn

Sanofi Moves To Replace Medivation’s Board As New Buyers Rumored

Small drugmaker Medivation ( MDVN ) continued to battle  Sanofi ‘s ( SNY ) hostile takeover bid Wednesday as the latter tried to replace its board, while big biotechs Celgene ( CELG ) and Gilead Sciences ( GILD ) were said to be thinking of joining the fray. Sanofi proposed eight candidates “who are willing to fully and fairly evaluate all of Medivation’s strategic options,” which it believes Medivation’s current board did not do when it unanimously rejected Sanofi’s unsolicited $9.3 billion bid on April 29. Medivation responded with a statement urging shareholders to reject the attempt, which it called “a tactic for Sanofi to facilitate its substantially inadequate and opportunistically timed proposal to acquire Medivation.” While Sanofi is the only suitor that’s gone public, anonymous sources have been telling the media that a variety of other companies are thinking of making a bid. On May 9, Medivation reportedly signed non-disclosures agreements with Pfizer ( PFE ) and Amgen ( AMGN ), implying that it is open to being bought by somebody other than Sanofi. On Wednesday Bloomberg said that Celgene and Gilead were talking to advisors about the idea, though they hadn’t actually approached the company. Both Celgene and Gilead have been urged by investors and analysts to make a sizable acquisition — especially Gilead, as its massive hepatitis C franchise is already eroding in the face of competition. Medivation’s current $1 billion in 12-month sales wouldn’t make that big of an impact on Gilead’s $33 billion top line, but much of the interest comes from Medivation’s future prospects: its prostate-cancer drug Xtandi is still ramping while the company studies its use in other diseases, and it also has a few earlier-stage drugs in the pipeline. Medivation stock, which has lately gone tight after a sharp run-up amid the buyout speculation, was down a fraction, near 62, in late morning trading on the stock market today . Sanofi was up 2%, near 41. Gilead was flat, near 86, and Celgene was up 1%, near 105.

AbbVie’s Biggest Drug Gets Patent Setback; Stock Tumbles

Shares of big pharma AbbVie ( ABBV ) nosedived Monday after the U.S. Patent and Trademark Office agreed to review a challenge to a patent on its best-selling drug. The Patent Trial and Appeal Board accepted a request for inter partes review (IPR) by generic-drug startup Coherus Biosciences ( CHRS ) on patent 8,889,135, or the “methods” patent, for rheumatoid-arthritis treatment Humira. The patent is due to expire in 2025, but if Coherus is successful, it could launch its biosimilar version of Humira earlier. That might not happen too soon, though, since the review normally takes a year and is then open to appeal. AbbVie stock, which had opened flat on the stock market today , abruptly dropped 4% after the news came out mid-morning, to near 60, and ended Tuesday’s session at 60.23, down 3.6%. Coherus’ more lightly traded stock jumped 16%, to 18.85. AbbVie is No. 1 in its Industry Group — find out more at IBD Stock Checkup . Humira is currently the top-selling drug in the world, with $14 billion in sales last year. Coherus is one of several companies developing biosimilars of Humira — others include privately held Boehringer Ingelheim, which has some outstanding IPR requests on several different patents, and Amgen ( AMGN ), whose IPR request on a different Humira patent was denied back in January. Coherus has also filed IPR requests on two other patents. “Keep in mind AbbVie also has methods patents which cover other approved Humira indications, such as Crohn’s (disease), and we would expect additional IPRs/litigation to commence prior to potential biosimilar approvals (Amgen’s Humira biosimilar could be approved later this year),” wrote Evercore ISI analyst Mark Schoenebaum in an email. “Thus, these IPRs will likely be the first of many legal actions against AbbVie’s methods patent estate.”

Pfizer Acquiring Anacor For Potential Blockbuster Eczema Drug

Big pharma Pfizer ( PFE ) said Monday that it’s acquiring small biopharma Anacor Pharmaceuticals ( ANAC ) for $4.5 billion in cash, sending the latter’s stock up more than 50% in early Monday trading. Pfizer agreed to pay $99.26 a share for Anacor, a 55% premium over Friday’s closing price. The total transaction value is $5.2 billion, assuming the conversion of Anacor’s outstanding convertible notes, Pfizer said. Anacor’s sole commercial product is a toenail-fungus ointment called Kerydin, distributed by Novartis ( NVS ), but Pfizer’s press release on the merger played up Anacor’s eczema treatment crisaborole, which is under FDA review due for completion by Jan. 7. “We believe the acquisition of Anacor represents an attractive opportunity to address a significant unmet medical need for a large patient population with mild-to-moderate atopic dermatitis, which currently has few safe topical treatments available,” said Albert Bourla, head of Pfizer’s innovative businesses, in the release. Pfizer estimates crisaborole could reach peak annual sales of $2 billion. The buyout adds another asset to Pfizer’s innovate drug business, which it is widely expected to separate from its established-products business sometime in the next few years. Pfizer has said that it will make a decision on whether to split by year’s end. Pfizer already has a significant presence in inflammation and immunology, including blockbuster rheumatoid arthritis treatments Enbrel (sold in partnership with Amgen ( AMGN )) and Xeljanz.  Regeneron Pharmaceuticals ( REGN ) recently reported strong late-stage data for its injectable drug dupilumab in atopic dermatitis, so while the market is currently underserved, it may soon become more competitive. Anacor stock was up 54.7% in opens trades  on the stock market today , near 99. Pfizer stock was down a fraction, near 33. Regeneron stock was up almost 3%.